Invention Grant
US08048905B2 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
- Patent Title: Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- Patent Title (中): 四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
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Application No.: US12317026Application Date: 2008-12-17
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Publication No.: US08048905B2Publication Date: 2011-11-01
- Inventor: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- Applicant: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- Applicant Address: US CA Palo Alto
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Current Assignee Address: US CA Palo Alto
- Agent Robert C. Hall
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A01N33/02 ; A61K31/41 ; A61K31/13 ; C07D257/04
Abstract:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
Public/Granted literature
- US20090163502A1 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists Public/Granted day:2009-06-25
Information query
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