Invention Grant
- Patent Title: Proton pump inhibitors
- Patent Title (中): 质子泵抑制剂
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Application No.: US11664346Application Date: 2005-09-30
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Publication No.: US08048909B2Publication Date: 2011-11-01
- Inventor: Masahiro Kajino , Atsushi Hasuoka , Terufumi Takagi
- Applicant: Masahiro Kajino , Atsushi Hasuoka , Terufumi Takagi
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent David G. Conlin; Dwight D. Kim
- Priority: JP2004-289169 20040930; JP2005-044740 20050221
- International Application: PCT/JP2005/018572 WO 20050930
- International Announcement: WO2006/036024 WO 20060406
- Main IPC: A61K31/40
- IPC: A61K31/40 ; C07D207/48 ; A61P1/04

Abstract:
A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof, or a prodrug thereof is provided.
Public/Granted literature
- US20080139639A1 Proton Pump Inhibitors Public/Granted day:2008-06-12
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