Invention Grant
US08048983B2 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
有权
HMGN2肽和相关分子，选择性地归属于肿瘤血管和肿瘤细胞
- Patent Title: HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
- Patent Title (中): HMGN2肽和相关分子，选择性地归属于肿瘤血管和肿瘤细胞
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Application No.: US12288547Application Date: 2008-10-20
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Publication No.: US08048983B2Publication Date: 2011-11-01
- Inventor: Erkki Ruoslahti , Kimmo Porkka , Sven Christian
- Applicant: Erkki Ruoslahti , Kimmo Porkka , Sven Christian
- Applicant Address: US CA La Jolla
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Jones Day
- Main IPC: C07K5/00
- IPC: C07K5/00 ; C07K14/00 ; G01N33/574
Abstract:
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.
Public/Granted literature
- US20090098633A1 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells Public/Granted day:2009-04-16
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