Example embodiments and methods are directed to irradiation target retention devices that may be inserted into conventional nuclear fuel rods and assemblies. Example embodiment devices may hold several irradiation targets for irradiation during operation of a nuclear core containing the assemblies and fuel rods having example embodiment irradiation target retention devices. Irradiation targets may substantially convert to useful radioisotopes upon exposure to neutron flux in the operating nuclear core and be removed and harvested from fuel rods after operation.