In a signal processing system, a set of channel signals from an array of sensors of different operating characteristics are processed in calibration circuitry that calculates individual average values of the channel signals and calculates an average of the individual average values of channel signals as a reference value. Reciprocal calculators calculate reciprocal values of the individual average values of the channel signals. Scaling circuitry scales the reciprocal values by the reference value to produce a set of amplitude calibration signals and scales the channel signals by the calibration signals respectively. As a result, the channel signals are normalized by their own average values and scaled by the reference value to produce a set of calibrated channel signals.