Systems and methods for facilitating visual detection of one or more catheter tips in relation to the morphology of an anatomical structure include locating reference catheters relative to heart tissue using an automated navigation support that draws upon prominent image features that are visible in the x-ray fluoroscopy images. The prominent features include catheter tips of reference catheters that are placed at known standard positions in relation to the anatomical structures. Based on the noted prominent features, the systems and methods achieve alignment of the anatomical structures, e.g., the heart morphology, with the interventional devices, e.g., ablation catheter(s) introduced by the physician, and generate a fused or overlaid image.