Invention Grant
- Patent Title: Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
- Patent Title (中): 缺氧诱导因子1α脯氨酰羟化酶晶体
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Application No.: US12473536Application Date: 2009-05-28
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Publication No.: US08050873B2Publication Date: 2011-11-01
- Inventor: Artem Gennady Evdokimov , Richard Masaru Kawamoto , Angelique Sun Boyer , Marlene Jan Mekel , Matthew Eugene Pokross , Richard Lee Walter, Jr.
- Applicant: Artem Gennady Evdokimov , Richard Masaru Kawamoto , Angelique Sun Boyer , Marlene Jan Mekel , Matthew Eugene Pokross , Richard Lee Walter, Jr.
- Applicant Address: US PR Fajardo
- Assignee: Warner Chilcott Company
- Current Assignee: Warner Chilcott Company
- Current Assignee Address: US PR Fajardo
- Agent Richard S. Echler
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G01N33/567 ; G06G7/58 ; C12Q1/26
Abstract:
The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.
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