Invention Grant
US08052994B2 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
有权
3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基 - 1,1'-联苯基] -3-羧酸双 - （单乙醇胺）
![3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/docs/US/2011-11-08/US08052994B2/abs.jpg.600x600.jpg)
- Patent Title: 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
- Patent Title (中): 3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基 - 1,1'-联苯基] -3-羧酸双 - （单乙醇胺）
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Application No.: US12607305Application Date: 2009-10-28
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Publication No.: US08052994B2Publication Date: 2011-11-08
- Inventor: Francis X. Muller , Shivakumar G. Kapsi
- Applicant: Francis X. Muller , Shivakumar G. Kapsi
- Applicant Address: US PA Philadelphia
- Assignee: GlaxoSmithKline LLC
- Current Assignee: GlaxoSmithKline LLC
- Current Assignee Address: US PA Philadelphia
- Agent Wayne J. Dustman; Edward R. Gimmi
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K31/4152 ; C07D231/38
![3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2011/11/08/US08052994B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
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