Invention Grant
- Patent Title: Methods for detecting a Mycobacterium tuberculosis infection
- Patent Title (中): 检测结核分枝杆菌感染的方法
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Application No.: US12282862Application Date: 2007-03-14
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Publication No.: US08053181B2Publication Date: 2011-11-08
- Inventor: David M. Lewinsohn , Deborah A. Lewinsohn
- Applicant: David M. Lewinsohn , Deborah A. Lewinsohn
- Applicant Address: US OR Portland US DC Washington
- Assignee: Oregon Health & Science University,The United States of America as represented by the Department of Veterans Affairs
- Current Assignee: Oregon Health & Science University,The United States of America as represented by the Department of Veterans Affairs
- Current Assignee Address: US OR Portland US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2007/006534 WO 20070314
- International Announcement: WO2007/106560 WO 20070920
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/53 ; G01N33/567 ; G01N33/554 ; G01N33/569
Abstract:
Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods can also include detecting Mtb polypeptides and polynucleotides. Reagents for the detection of an Mtb infection are also disclosed.
Public/Granted literature
- US20090324503A1 METHODS FOR DETECTING A MYCOBACTERIUM TUBERCULOSIS INFECTION Public/Granted day:2009-12-31
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