Invention Grant
- Patent Title: Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same
- Patent Title (中): 对组蛋白脱乙酰酶具有抑制活性的萘氧基丙烯基衍生物及其组合物
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Application No.: US12513021Application Date: 2007-11-01
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Publication No.: US08053435B2Publication Date: 2011-11-08
- Inventor: Cheol Hae Lee , Hee Jung Jung , Jae Hak Kim , Won Jang Jeong , Joong Myung Cho , Seong Gu Ro , Young Lan Hyun , Cheol Soon Lee , Dongkyu Shin
- Applicant: Cheol Hae Lee , Hee Jung Jung , Jae Hak Kim , Won Jang Jeong , Joong Myung Cho , Seong Gu Ro , Young Lan Hyun , Cheol Soon Lee , Dongkyu Shin
- Applicant Address: KR Daejeon KR Seoul
- Assignee: Korea Research Institute of Chemical Technology,Crystalgenomics, Inc.
- Current Assignee: Korea Research Institute of Chemical Technology,Crystalgenomics, Inc.
- Current Assignee Address: KR Daejeon KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2006-0108182 20061103; KR10-2006-0108228 20061103; KR10-2006-0108230 20061103; KR10-2006-0109436 20061107
- International Application: PCT/KR2007/005491 WO 20071101
- International Announcement: WO2008/054154 WO 20080508
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A61K31/341 ; A61K31/381 ; A61K31/4164 ; A61K31/4166 ; A61K31/40 ; A61K31/4468 ; A61K31/5375 ; C07D207/50 ; C07D233/88 ; C07D295/027 ; C07D211/98 ; C07D307/66 ; C07D333/36
Abstract:
The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.
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