Invention Grant
US08053457B2 3-imidazolyl-indoles for the treatment of proliferative diseases
失效
3-咪唑基 - 吲哚，用于治疗增殖性疾病
- Patent Title: 3-imidazolyl-indoles for the treatment of proliferative diseases
- Patent Title (中): 3-咪唑基 - 吲哚，用于治疗增殖性疾病
-
Application No.: US12593721Application Date: 2008-03-27
-
Publication No.: US08053457B2Publication Date: 2011-11-08
- Inventor: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
- Applicant: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Priority: EP07105269 20070329
- International Application: PCT/EP2008/053667 WO 20080327
- International Announcement: WO2008/119741 WO 20081009
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/5377 ; A61K31/496 ; A61K31/506 ; C07D401/14 ; C07D403/14
Abstract:
The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
Public/Granted literature
- US20100125064A1 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases Public/Granted day:2010-05-20
Information query
