Invention Grant
- Patent Title: Bacterial packaging strains useful for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof
- Patent Title (中): 用于产生和产生重组双链RNA核衣壳的细菌包装菌株及其用途
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Application No.: US11284817Application Date: 2005-11-23
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Publication No.: US08053568B2Publication Date: 2011-11-08
- Inventor: David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
- Applicant: David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
- Applicant Address: US MD Rockville
- Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee Address: US MD Rockville
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04 ; A61K38/16
Abstract:
Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
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