Invention Grant
- Patent Title: Process for preparation of diphosphine compounds and intermediates for the process
- Patent Title (中): 制备二膦化合物和中间体的方法
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Application No.: US12694658Application Date: 2010-01-27
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Publication No.: US08053604B2Publication Date: 2011-11-08
- Inventor: Mitsutaka Goto , Mitsuhisa Yamano
- Applicant: Mitsutaka Goto , Mitsuhisa Yamano
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2001-374909 20011207
- Main IPC: C07F5/02
- IPC: C07F5/02 ; C07F9/50
Abstract:
A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
Public/Granted literature
- US20100125153A1 PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS Public/Granted day:2010-05-20
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