The present invention discloses a wavelength-multiplex and space-multiplex holographic storage device, which comprises a storage medium, a plurality of signal light beams and at least one reference light beam. The signal light beams have different wavelengths and illuminate the storage medium. The reference light beam illuminates the storage medium and interferes with the signal light beams to form a plurality of interference patterns. The interference patterns are respectively stored on different-depth storage layers of the storage medium. The present invention not only has a high access rate but also has a large storage capacity.