A wireless communication system, a method, and a tangible machine-readable medium thereof for transmitting data based on a frame structure of a multi-hop relay standard are provided. The wireless communication system comprises a base station (BS), a relay station (RS), and a mobile station (MS). The frame structure comprises a relay station map (RS-MAP) frame and an MS sub-frame. The RS-MAP frame describes the frame structure. The MS sub-frame is used for transmitting the first data between the BS and the MS and is used for transmitting a second data between the RS and the MS according to the content of the RS-MAP frame. A part of the second data is the same as the first data.