Certain embodiments of the present disclosure relate to methods for mitigating interference of signals transmitted to a mobile station (MS) from a plurality of neighboring base stations. By applying a proposed spatio-frequency modulation (SFM) technique at a serving base station (BS) and at each interfering BS, a co-channel interference (CCI) from interfering base stations can be efficiently mitigated at the MS and signal transmitted from the serving BS can be more accurately decoded.