A manifest for a multi-dose medication order is disclosed. The manifest may serve as a single recipe or roadmap for the prescriptions and containers required for a multi-dose medicament order. The manifest may include a representation of intersecting prescription and container matrices, with each intersecting entry including an indication of a number of medicaments of an individual prescription mapped to be packaged into an individual container. Machine-readable identifiers and fields for different levels of approval may be included on the manifest. Dosing regime parameters may be visually differentiated. Methods and systems for creating a manifest and using the manifest in filling a multi-dose medicament order are also disclosed.