Invention Grant
US08067555B2 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
有权
部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用
- Patent Title: Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
- Patent Title (中): 部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用
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Application No.: US11882978Application Date: 2007-08-08
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Publication No.: US08067555B2Publication Date: 2011-11-29
- Inventor: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- Applicant: Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
- Applicant Address: CH Lugano
- Assignee: Sigma-Tau Research Switzerland S.A.
- Current Assignee: Sigma-Tau Research Switzerland S.A.
- Current Assignee Address: CH Lugano
- Agency: Lucas & Mercanti, LLP
- Priority: ITRM00A0041 20000125; WOPCT/IT01/00034 20010124; WOPCT/IT01/00472 20010912
- Main IPC: C08B37/10
- IPC: C08B37/10 ; C07H5/04
Abstract:
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
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