Invention Grant
- Patent Title: Process for the production of benzopyran-2-ol derivatives
- Patent Title (中): 苯并吡喃-2-醇衍生物的制备方法
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Application No.: US12302228Application Date: 2007-05-21
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Publication No.: US08067594B2Publication Date: 2011-11-29
- Inventor: Jens Bertil Ahman , Barry Richard Dillon , Alan John Pettman
- Applicant: Jens Bertil Ahman , Barry Richard Dillon , Alan John Pettman
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Jennifer A. Kispert; Richard V. Zanzalari
- International Application: PCT/IB2007/001379 WO 20070521
- International Announcement: WO2007/138440 WO 20071206
- Main IPC: C07D311/20
- IPC: C07D311/20 ; C07D311/58 ; C07C215/54 ; C07C213/02 ; C07C219/28

Abstract:
The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX represents hydroxy or O−M+, in which M+ is a cation selected from Li+, Na+ and K+, and Y is as defined above; with trans-cinnamaldehyde (III), in the presence of a secondary amine compound; then (ii) treating the product of the preceding step with acid to afford the compound of formula (I). The above process may also be used in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.
Public/Granted literature
- US20090306384A1 Process for the Production of Benzopyran-2-ol Derivatives Public/Granted day:2009-12-10
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