Invention Grant
- Patent Title: Heterofused piperidines as orexin antagonists
- Patent Title (中): 异味的哌啶作为食欲肽拮抗剂
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Application No.: US12056324Application Date: 2008-03-27
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Publication No.: US08067598B2Publication Date: 2011-11-29
- Inventor: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant Address: US NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent Goerge W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07105596 20070404
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D513/04 ; A61K31/4365 ; A61K31/437 ; A61K31/4375

Abstract:
The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
Public/Granted literature
- US20080249125A1 HETEROCYCLIC DERIVATIVES AS OREXIN ANTAGONISTS Public/Granted day:2008-10-09
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