Invention Grant
- Patent Title: Hedgehog pathway antagonists
- Patent Title (中): 刺猬途径拮抗剂
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Application No.: US10573945Application Date: 2004-09-29
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Publication No.: US08067608B2Publication Date: 2011-11-29
- Inventor: Philip A. Beachy , James K. Chen , Anssi J. Taipale
- Applicant: Philip A. Beachy , James K. Chen , Anssi J. Taipale
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: DLA Piper LLP (US)
- International Application: PCT/US2004/032482 WO 20040929
- International Announcement: WO2005/033288 WO 20050414
- Main IPC: C07D213/56
- IPC: C07D213/56 ; A61K31/44
Abstract:
Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function.
Public/Granted literature
- US20070232661A1 Hedgehog Pathway Antagonists Public/Granted day:2007-10-04
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