Invention Grant
US08067628B2 Water-soluble binuclear nitrosyl iron complexes with natural aliphatic thiolyls possessing cytotoxic, apoptotic and no-donor activity
有权
水溶性双核亚硝酰基铁配合物与天然脂肪族硫醚具有细胞毒性，凋亡和非供体活性
- Patent Title: Water-soluble binuclear nitrosyl iron complexes with natural aliphatic thiolyls possessing cytotoxic, apoptotic and no-donor activity
- Patent Title (中): 水溶性双核亚硝酰基铁配合物与天然脂肪族硫醚具有细胞毒性，凋亡和非供体活性
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Application No.: US12602867Application Date: 2008-06-02
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Publication No.: US08067628B2Publication Date: 2011-11-29
- Inventor: Natalia Alexeevna Sanina , Konstantin Alexandrovich Lysenko , Olga Stepanovna Zhukova , Tatyana Nikolaevna Rudneva , Nina Sergeevna Emelianova , Sergei Mikhailovich Aldoshin
- Applicant: Natalia Alexeevna Sanina , Konstantin Alexandrovich Lysenko , Olga Stepanovna Zhukova , Tatyana Nikolaevna Rudneva , Nina Sergeevna Emelianova , Sergei Mikhailovich Aldoshin
- Applicant Address: RU Moskovskaya Obl.
- Assignee: Institute of Problems of Chemcial Physics RAS (IPCP RAS)
- Current Assignee: Institute of Problems of Chemcial Physics RAS (IPCP RAS)
- Current Assignee Address: RU Moskovskaya Obl.
- Agency: Osha • Liang LLP
- International Application: PCT/RU2008/000338 WO 20080602
- International Announcement: WO2009/148346 WO 20091210
- Main IPC: C07F15/00
- IPC: C07F15/00 ; A61K31/295
Abstract:
The present invention relates to water-soluble binuclear cationic nitrosyl iron complexes with natural aliphatic thiolyls of general formula [Fe2(SR)2(NO)4]SO4, wherein R is sulfur-containing aliphatic ligands of natural origin, preferably, cystamine or penicillamine, to a method for the preparation thereof, to use thereof as an anticancer agent, to an apoptosis inducer, to a pharmaceutical composition comprising said complexes in an effective amount, and to a kit useful for the treatment of cancer diseases.
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