Invention Grant
US08067631B2 Method of rapid methylation of alkene compound and kit for PET tracer preparation using the same
失效
烯烃化合物的快速甲基化方法和使用其的PET示踪剂制备试剂盒
- Patent Title: Method of rapid methylation of alkene compound and kit for PET tracer preparation using the same
- Patent Title (中): 烯烃化合物的快速甲基化方法和使用其的PET示踪剂制备试剂盒
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Application No.: US12090642Application Date: 2006-10-06
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Publication No.: US08067631B2Publication Date: 2011-11-29
- Inventor: Masaaki Suzuki , Takamitsu Hosoya
- Applicant: Masaaki Suzuki , Takamitsu Hosoya
- Applicant Address: JP Gifu-shi, Gifu
- Assignee: Gifu University
- Current Assignee: Gifu University
- Current Assignee Address: JP Gifu-shi, Gifu
- Agency: Quarles & Brady LLP
- Agent Gavin J. Milczarek-Desai
- Priority: JP2005-306670 20051021
- International Application: PCT/JP2006/320104 WO 20061006
- International Announcement: WO2007/046258 WO 20070426
- Main IPC: C07C69/74
- IPC: C07C69/74 ; C07C45/00 ; C07C35/00 ; C07C11/02
Abstract:
To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP2 (alkenyl) and SP3 (alkyl) carbon atoms rapidly and in a high yield. Methyl iodide and an alkenyltrialkylstannane are subjected to cross coupling in an aprotic polar solvent in the presence of a palladium complex having a valence of 0, a phosphine ligand, a cuprous halide, and a carbonate and/or alkali metal fluoride.
Public/Granted literature
- US20090238759A1 Method of Rapid Methylation of Alkene Compound and Kit for PET Tracer Preparation Using the Same Public/Granted day:2009-09-24
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