An booster/amplifier receives a plurality of RF signals, including a subject RF signal. A location-based signal spectrum is determined by performing either a frequency scan or an information lookup operation. An initial filter bandwidth for the booster/amplifier is set based at least in part on the determined signal spectrum and a target time delay interference. In one embodiment, the initial filter bandwidth is set such that both the TDI and ACI are optimized/minimized. The initial filter bandwidth subsequently may be adjusted from its initial value based on actual measured ACI and/or TDI values.