Enhanced frequency division multiple access (EFDMA) is a multiplexing scheme that sends modulation symbols in the time domain and achieves a lower PAPR than OFDM. An EFDMA symbol occupies multiple subband groups that are spaced apart in a frequency band, with each subband group containing multiple adjacent subbands. To generate an EFDMA symbol, multiple modulation symbols are mapped onto a first sequence of symbols. A transform (e.g., a DFT) is performed on the first sequence to obtain a second sequence of values. The values in the second sequence corresponding to the subbands used for the EFDMA symbol are retained, and the remaining values are zeroed out to obtain a third sequence of values. An inverse transform (e.g., an IDFT) is performed on the third sequence to obtain a fourth sequence of samples. A phase ramp may be applied on the fourth sequence, and a cyclic prefix is appended to form the EFDMA symbol.