The present invention discloses a multi-mode coexistence method of a multi-mode communication device comprising steps of: setting priorities of frequency usage for all modes supported by the multi-mode communication device; determining a channel where a signal of a lower priority mode are interfered with by that of a higher priority mode; performing frequency hopping to outside said determined channel by the lower priority mode. The invention allows signals of various modes to coexist in the multi-mode communication device without modifying the existing RF reception system, and thus reduces the system cost and implementation complexity.