Disclosed are method and apparatus for motion correction of Digital Subtracted Angiography (DSA) images. Prior to display of DSA image frames, a pixel shift vector is calculated for each fill frame. For a fill frame in which a pixel shift vector cannot be directly calculated, an approximate pixel shift vector is interpolated between, or extrapolated from, other pixel shift vectors. A mask frame is shifted by a pixel shift vector. The resulting shifted mask frame is subtracted from the corresponding fill frame to generate a motion-corrected subtracted frame, which is then displayed on a video display. Motion correction is performed prior to diagnostic review.