A remote control communicates via two-way communication with a controller for a bed facility to allow a user of the remote control to control a function of the bed facility. Adjustable features of an adjustable bed can be controlled through the two-way communication. Inflation or other features of an air mattress can be controlled through the two-way communication. Two-way communication is supported by either a wired connection or a wireless connection such as Bluetooth, USB, ultra wideband, and the like. The two-way communication also supports the remote control controlling a second system that is associated with the adjustable bed.