A method for preoperatively characterizing an individual patient's biomechanic function in preparation of implanting a prosthesis is provided. The method includes subjecting a patient to various activities, recording relative positions of anatomy during the various activities, measuring force environments responsive to the patient's anatomy and affected area during the various activities, characterizing the patient's biomechanic function from the relative positions and corresponding force environments, inputting the measured force environments, relative positions of knee anatomy, and patient's biomechanic function characterization into the one or more computer simulation models, inputting a computer model of the prosthesis into the one or more computer simulation models, and manipulating the placement of the prosthesis in the computer simulation using the patient's biomechanic function characterization and the computer model of the prosthesis to approximate a preferred biomechanical fit of the prosthesis.