Invention Grant
US08080240B2 Parvovirus methods and compositions for killing neoplastic cells
有权
用于杀死肿瘤细胞的细小病毒方法和组合物
- Patent Title: Parvovirus methods and compositions for killing neoplastic cells
- Patent Title (中): 用于杀死肿瘤细胞的细小病毒方法和组合物
-
Application No.: US11577782Application Date: 2005-10-21
-
Publication No.: US08080240B2Publication Date: 2011-12-20
- Inventor: Craig M. Meyers , Samina Alam
- Applicant: Craig M. Meyers , Samina Alam
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: McKee, Voorhees & Sease, P.L.C.
- International Application: PCT/US2005/037930 WO 20051021
- International Announcement: WO2006/047301 WO 20060504
- Main IPC: A61K39/04
- IPC: A61K39/04 ; C12N15/37
Abstract:
According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursers, while leaving healthy cells intact. The invention thus comprises a method of killing cancer and other neoplastic and preneoplastic cells by administration of AAV2 virus, viral particles, products or replication incompetent vectors derived there from to said cells, and pharmaceutical compositions comprising the same.
Public/Granted literature
- US20090117081A1 PARVOVIRUS METHODS AND COMPOSITIONS FOR KILLING NEOPLASTIC CELLS Public/Granted day:2009-05-07
Information query
