Invention Grant
- Patent Title: Methods for production of oligonucleotides
- Patent Title (中): 生产寡核苷酸的方法
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Application No.: US11911521Application Date: 2006-04-10
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Publication No.: US08080393B2Publication Date: 2011-12-20
- Inventor: Jorn Erland Koch , Magnus Stougaard , Jakob Schwalbe Lohmann
- Applicant: Jorn Erland Koch , Magnus Stougaard , Jakob Schwalbe Lohmann
- Applicant Address: SE Uppsala
- Assignee: Olink AB
- Current Assignee: Olink AB
- Current Assignee Address: SE Uppsala
- Agency: Sunstein Kann Murphy & Timbers LLP
- Priority: DK200500521 20050412
- International Application: PCT/DK2006/050012 WO 20060410
- International Announcement: WO2006/108423 WO 20061019
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C07H21/02
Abstract:
The present invention relates to production of oligonucleotides using rolling circle replication, wherein synthesised multimeric oligonucleotides are reduced to mononucleotides using a nicking cassette. Thus, the invention provides a method for the production of oligonucleotides, enabling efficient amplification of oligonucleotides at lengths up to at least 1000 nucleotides and in high amounts contained within a nicking cassette.
Public/Granted literature
- US20100028953A1 Methods for production of oligonucleotides Public/Granted day:2010-02-04
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