Invention Grant
- Patent Title: Prodrugs of CGRP receptor antagonists
- Patent Title (中): CGRP受体拮抗剂的前药
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Application No.: US12864120Application Date: 2009-02-04
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Publication No.: US08080544B2Publication Date: 2011-12-20
- Inventor: Ian M. Bell , Steven N. Gallicchio , Valentino J. Stella
- Applicant: Ian M. Bell , Steven N. Gallicchio , Valentino J. Stella
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Gerard M. Devlin; Raynard Yuro
- International Application: PCT/US2009/033008 WO 20090204
- International Announcement: WO2009/100090 WO 20090813
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61P25/06 ; C07D471/04
Abstract:
Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20100298269A1 PRODRUGS OF CGRP RECEPTOR ANTAGONISTS Public/Granted day:2010-11-25
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