Invention Grant
US08080559B2 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
失效
5（S） - （2'-羟基乙氧基）-20（S） - 喜树碱及其制备及用于治疗癌症
- Patent Title: 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
- Patent Title (中): 5（S） - （2'-羟基乙氧基）-20（S） - 喜树碱及其制备及用于治疗癌症
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Application No.: US12577399Application Date: 2009-10-12
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Publication No.: US08080559B2Publication Date: 2011-12-20
- Inventor: Venkateswarlu Akella , Shanavas Alikunju , Ajaya Kumar Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- Applicant: Venkateswarlu Akella , Shanavas Alikunju , Ajaya Kumar Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- Applicant Address: IN Hyderabad, Andhra Pradesh US NJ Bridgewater
- Assignee: Dr. Reddy's Laboratories Limited,Dr. Reddy's Laboratories, Inc.
- Current Assignee: Dr. Reddy's Laboratories Limited,Dr. Reddy's Laboratories, Inc.
- Current Assignee Address: IN Hyderabad, Andhra Pradesh US NJ Bridgewater
- Agent Balaram Gupta; Robert A. Franks; Thomas C. McKenzie
- Priority: IN897/CHE/2006 20060524
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D491/22
Abstract:
A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
Public/Granted literature
- US20100063083A1 5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN AND ITS PREPARATION AND USE FOR THE TREATMENT OF CANCER Public/Granted day:2010-03-11
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