Invention Grant
- Patent Title: Water-soluble prodrugs of florfenicol and its analogs
- Patent Title (中): 氟苯尼考及其类似物的水溶性前药
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Application No.: US11953962Application Date: 2007-12-11
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Publication No.: US08084643B2Publication Date: 2011-12-27
- Inventor: Tomasz W. Glinka , Jason Z. Zhang
- Applicant: Tomasz W. Glinka , Jason Z. Zhang
- Applicant Address: US NJ Summit
- Assignee: Intervet Inc.
- Current Assignee: Intervet Inc.
- Current Assignee Address: US NJ Summit
- Agent David Kerwick
- Main IPC: A61K31/21
- IPC: A61K31/21 ; C07C233/00

Abstract:
The present invention discloses certain novel prodrugs of florfenicol and/or of florfenicol analogs, including prodrugs of salts pharmaceutically acceptable salts of florfenicol and its analogs, including nitrogen-containing esters of the secondary alcohol group of florfenicol and of its analogs, and pharmaceutically acceptable salts thereof, compositions containing them, and methods of administering them to subjects. In particular embodiments the prodrugs are sufficiently water-soluble to serve the functions needed of a water-soluble prodrug of florfenicol or of a water-soluble prodrug of a florfenicol analog. A certain subclass of the compounds also possesses the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing florfenicol or the florfenicol analog in question.
Public/Granted literature
- US20080188556A1 Water-Soluble Prodrugs of Florfenicol and its Analogs Public/Granted day:2008-08-07
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