A handling device of a printing press, in particular for handling printing plates during an automated change of printing plates on a printing unit of a printing press, is disclosed. The handling device has a manipulator arm, where a manipulator head is allocated to one end of the manipulator arm, which head features a handling element, in particular a holding element for printing plates. The manipulator arm is of a multi-piece design of several segments, where a swivel axis is included on each end of each segment, around which axis at least the respective segment can be swiveled, and where a separate drive for providing the respective swivel motion is allocated to each swivel axis.