Invention Grant
- Patent Title: Fc variants with altered binding to FcRn
- Patent Title (中): Fc变体与FcRn结合改变
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Application No.: US13008165Application Date: 2011-01-18
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Publication No.: US08088376B2Publication Date: 2012-01-03
- Inventor: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agent Robin M. Silva; Gargi Talukder
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/40 ; C12P21/08
Abstract:
The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
Public/Granted literature
- US20110110928A1 FC VARIANTS WITH ALTERED BINDING TO FCRN Public/Granted day:2011-05-12
Information query
