Invention Grant
- Patent Title: Mutated E. coli heat-labile enterotoxin
- Patent Title (中): 突变大肠杆菌热不稳定肠毒素
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Application No.: US12120953Application Date: 2008-05-15
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Publication No.: US08088394B2Publication Date: 2012-01-03
- Inventor: Yu-Shen Hsu , Young-Sun Lin , Ta-Tung Yuan
- Applicant: Yu-Shen Hsu , Young-Sun Lin , Ta-Tung Yuan
- Applicant Address: TW Xizhi
- Assignee: Development Center for Biotechnology
- Current Assignee: Development Center for Biotechnology
- Current Assignee Address: TW Xizhi
- Agency: Occhiuti Rochlicek & Tsao LLP
- Priority: TW95139707A 20061027
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/02 ; A61K39/108 ; C07H21/02 ; C07H21/04 ; C12N15/00
Abstract:
This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.
Public/Granted literature
- US20080220519A1 MUTATED E. COLI HEAT-LABILE ENTEROTOXIN Public/Granted day:2008-09-11
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