Invention Grant
- Patent Title: Human immortalised neural precursor cell line
- Patent Title (中): 人类永生化神经前体细胞系
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Application No.: US11910285Application Date: 2006-03-30
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Publication No.: US08088567B2Publication Date: 2012-01-03
- Inventor: Bengt Juliusson
- Applicant: Bengt Juliusson
- Applicant Address: DK Ballerup
- Assignee: NsGene A/S
- Current Assignee: NsGene A/S
- Current Assignee Address: DK Ballerup
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- Priority: DK200500461 20050401; DK200500523 20050412
- International Application: PCT/DK2006/000185 WO 20060330
- International Announcement: WO2006/102902 WO 20061005
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/00

Abstract:
The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a neural progenitor cell line capable of differentiating into to astrocytes and neurons including dopaminergic neurons. NGC-407 cells are capable of migrating to glioblastoma tumours implanted into rat brains and form gap junctions with the tumour cells. NGC-407 cells expressing a suicide gene can be be used for delivering activated prodrugs in the form of activated nucleoside analogs to tumours.
Public/Granted literature
- US20110182983A1 HUMAN IMMORTALISED NEURAL PRECURSOR CELL LINE Public/Granted day:2011-07-28
Information query
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