Invention Grant
US08088567B2 Human immortalised neural precursor cell line 有权
人类永生化神经前体细胞系

  • Patent Title: Human immortalised neural precursor cell line
  • Patent Title (中): 人类永生化神经前体细胞系
  • Application No.: US11910285
    Application Date: 2006-03-30
  • Publication No.: US08088567B2
    Publication Date: 2012-01-03
  • Inventor: Bengt Juliusson
  • Applicant: Bengt Juliusson
  • Applicant Address: DK Ballerup
  • Assignee: NsGene A/S
  • Current Assignee: NsGene A/S
  • Current Assignee Address: DK Ballerup
  • Agency: Clark & Elbing LLP
  • Agent Kristina Bieker-Brady
  • Priority: DK200500461 20050401; DK200500523 20050412
  • International Application: PCT/DK2006/000185 WO 20060330
  • International Announcement: WO2006/102902 WO 20061005
  • Main IPC: C12N15/00
  • IPC: C12N15/00 C12N5/00
Human immortalised neural precursor cell line
Abstract:
The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a neural progenitor cell line capable of differentiating into to astrocytes and neurons including dopaminergic neurons. NGC-407 cells are capable of migrating to glioblastoma tumours implanted into rat brains and form gap junctions with the tumour cells. NGC-407 cells expressing a suicide gene can be be used for delivering activated prodrugs in the form of activated nucleoside analogs to tumours.
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