Invention Grant
- Patent Title: LTBP2 as a biomarker and diagnostic target
- Patent Title (中): LTBP2作为生物标志物和诊断靶标
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Application No.: US12444596Application Date: 2007-10-02
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Publication No.: US08088584B2Publication Date: 2012-01-03
- Inventor: Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
- Applicant: Stefan Golz , Holger Summer , Andreas Geerts , Ulf Brüggemeier , Barbara Albrecht-Küpper , Martina Klein , Sonja Steppan , Peter Ellinghaus , Donatella D'Urso , Michael Seewald , Hendrik Milting
- Applicant Address: DE Berlin
- Assignee: Bayer Schering Pharma Aktiengesellschaft
- Current Assignee: Bayer Schering Pharma Aktiengesellschaft
- Current Assignee Address: DE Berlin
- Agency: Banner & Witcoff, Ltd.
- Priority: EP06021595 20061016
- International Application: PCT/EP2007/008558 WO 20071002
- International Announcement: WO2008/046509 WO 20080424
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07K14/47 ; C07H21/04
Abstract:
The invention provides LTBP2, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.
Public/Granted literature
- US20100028264A1 LTBP2 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET Public/Granted day:2010-02-04
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