Invention Grant
US08088604B2 Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
有权
定义的单分散肝素聚合物和具有多糖合酶的非天然聚合物的生产
- Patent Title: Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
- Patent Title (中): 定义的单分散肝素聚合物和具有多糖合酶的非天然聚合物的生产
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Application No.: US11906704Application Date: 2007-10-03
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Publication No.: US08088604B2Publication Date: 2012-01-03
- Inventor: Paul L. DeAngelis , Alison Sismey-Ragatz
- Applicant: Paul L. DeAngelis , Alison Sismey-Ragatz
- Applicant Address: US OK Norman
- Assignee: The Board of Regents of the University of Oklahoma
- Current Assignee: The Board of Regents of the University of Oklahoma
- Current Assignee Address: US OK Norman
- Agency: Dunlap Codding, P.C.
- Main IPC: C12P19/18
- IPC: C12P19/18 ; C12P19/00 ; C12P19/04
Abstract:
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size. The present invention also relates to methodology for polymer grafting by a polysaccharide synthase to form glycosaminoglycan polymers having an unnatural structure.
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