Invention Grant
US08088610B2 Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate
有权
用于生产（S，E）-2-（3-（3-（2-（7-氯喹啉-2-基）乙烯基）苯基）-3-羟基丙基）苯甲酸甲酯的酮还原酶
- Patent Title: Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate
- Patent Title (中): 用于生产（S，E）-2-（3-（3-（2-（7-氯喹啉-2-基）乙烯基）苯基）-3-羟基丙基）苯甲酸甲酯的酮还原酶
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Application No.: US12240986Application Date: 2008-09-29
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Publication No.: US08088610B2Publication Date: 2012-01-03
- Inventor: Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James LaLonde , Gjalt W. Huisman
- Applicant: Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James LaLonde , Gjalt W. Huisman
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N9/04 ; C12N1/20 ; C12N15/00 ; C07H21/04
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Public/Granted literature
- US20090155863A1 KETOREDUCTASE POLYPEPTIDES AND USES THEREOF Public/Granted day:2009-06-18
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