Invention Grant
US08088617B2 Antibodies that bind the glutamate ligand binding region of Notch1
有权
结合Notch1的谷氨酸配体结合区的抗体
- Patent Title: Antibodies that bind the glutamate ligand binding region of Notch1
- Patent Title (中): 结合Notch1的谷氨酸配体结合区的抗体
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Application No.: US12010421Application Date: 2008-01-24
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Publication No.: US08088617B2Publication Date: 2012-01-03
- Inventor: Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
- Applicant: Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K16/28 ; C12P21/00 ; C12P21/08 ; C12N5/07
Abstract:
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
Public/Granted literature
- US20090047285A1 Compositions and methods for diagnosing and treating cancer Public/Granted day:2009-02-19
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