Invention Grant
- Patent Title: Anti-IL 13 antibodies and uses thereof
- Patent Title (中): 抗IL 13抗体及其用途
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Application No.: US12240604Application Date: 2008-09-29
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Publication No.: US08088618B2Publication Date: 2012-01-03
- Inventor: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- Applicant: Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C07K16/24

Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Public/Granted literature
- US20110014199A1 NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF Public/Granted day:2011-01-20
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