A fabric, particularly for items of clothing and shoes, including: a first inner layer, to be directed toward the body of the user, which is substantially hydrophobic and breathable and suitable to direct liquid-phase and vapor-phase perspiration away from the user of an item of clothing or the like produced with the fabric, a second intermediate spacing layer, which is substantially hydrophobic and transfers the liquid-phase perspiration from the first inner layer toward a third outer layer and defines preferential passages for vapor-phase perspiration from the first layer outwardly, and a third outer layer, which is substantially hydrophilic and suitable for permeation of vapor-phase perspiration, for absorbing liquid-phase perspiration that arrives from the first layer, and for distributing the liquid-phase perspiration over a large surface thereof so that it can evaporate outwardly.