Invention Grant
- Patent Title: CTLA-4 protein variants
- Patent Title (中): CTLA-4蛋白变体
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Application No.: US12446216Application Date: 2007-10-22
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Publication No.: US08088736B2Publication Date: 2012-01-03
- Inventor: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
- Applicant: Ruth Franks , Mark Terence Liddament , Lutz Ulrich Jochen Wilhelm Jermutus , Andrew Grier Buchanan
- Applicant Address: GB Cambridge
- Assignee: MedImmune Limited
- Current Assignee: MedImmune Limited
- Current Assignee Address: GB Cambridge
- Agency: Klarquist Sparkman, LLP
- Priority: GB0620934.0 20061020
- International Application: PCT/GB2007/004023 WO 20071022
- International Announcement: WO2008/047150 WO 20080424
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/47 ; C12P21/04 ; C12P21/06 ; G01N33/53
Abstract:
Protein variants of CTLA-4, which show increased activity compared to wild-type in a cell assay and which exhibit increased stability. Such variants are useful for treatment of disorders whereby attenuation of the T cell response would be beneficial.
Public/Granted literature
- US20100322893A1 CTLA-4 PROTEIN VARIANTS Public/Granted day:2010-12-23
Information query
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