Invention Grant
- Patent Title: Compositions, methods and kits relating to Her-2 cleavage
- Patent Title (中): 与Her-2切割有关的组合物，方法和试剂盒
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Application No.: US10817718Application Date: 2004-04-02
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Publication No.: US08088737B2Publication Date: 2012-01-03
- Inventor: Steven M. Friedman , Peggy A. Scherle , Xiangdong Liu , Timothy C. Burn , Reid Huber , Phillip C. C. Liu , Gregory F. Hollis , Krishna Vaddi , Jordan S. Fridman
- Applicant: Steven M. Friedman , Peggy A. Scherle , Xiangdong Liu , Timothy C. Burn , Reid Huber , Phillip C. C. Liu , Gregory F. Hollis , Krishna Vaddi , Jordan S. Fridman
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: A01N61/00
- IPC: A01N61/00 ; A61K31/00 ; A61K38/00 ; A61K39/395 ; G01N33/48
Abstract:
The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.
Public/Granted literature
- US20040247602A1 Compositions, methods and kits relating to Her-2 cleavage Public/Granted day:2004-12-09
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