Invention Grant
US08088760B2 Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP)
有权
聚（ADP-核糖）聚合酶（PARP）的苯并恶唑甲酰胺抑制剂
- Patent Title: Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP)
- Patent Title (中): 聚（ADP-核糖）聚合酶（PARP）的苯并恶唑甲酰胺抑制剂
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Application No.: US12355692Application Date: 2009-01-16
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Publication No.: US08088760B2Publication Date: 2012-01-03
- Inventor: Daniel Chu , Bing Wang
- Applicant: Daniel Chu , Bing Wang
- Applicant Address: US CA Novato
- Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee Address: US CA Novato
- Agency: Jones Day
- Main IPC: A61K31/422
- IPC: A61K31/422 ; A61K31/423 ; A61K31/496 ; C07D263/54 ; C07D413/02 ; A61P35/00
Abstract:
A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Public/Granted literature
- US20090197863A1 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) Public/Granted day:2009-08-06
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