Invention Grant
- Patent Title: Enzyme inhibitors
- Patent Title (中): 酶抑制剂
-
Application No.: US12158339Application Date: 2006-12-21
-
Publication No.: US08088761B2Publication Date: 2012-01-03
- Inventor: Vassilios Bavetsias , Edward McDonald , Spyridon Linardopoulos
- Applicant: Vassilios Bavetsias , Edward McDonald , Spyridon Linardopoulos
- Applicant Address: GB
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB
- Agency: Banner & Witcoff, Ltd.
- Priority: GB0526169.8 20051222; GB0620884.7 20061020
- International Application: PCT/GB2006/004854 WO 20061221
- International Announcement: WO2007/072017 WO 20070628
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61K31/496 ; A61K31/551 ; A61P37/08 ; C07D471/04

Abstract:
Compounds of formula (I), are aurora kinase inhibitors: wherein X is —N—, —CH2-N—, —CH2-CH—, or —CH—; R1 is a radical of formula (IA) wherein Z is —CH2-, —NH—, -0-, —S(O)— —S—, —S(O)2 or a divalent monocyclic carbocyclic or heterocyclic radical having 3-7 ring atoms; Alk is an optionally substituted divalent C1-C6 alkylene radical; A is hydrogen or an optionally substituted monocyclic carbocyclic or heterocyclic ring having 5-7 ring atoms; r, s and t are independently 0 or 1, provided that when A is hydrogen then at least one of r and s is 1; R2 is halogen, —CN, —CF3, —OCH3, or cyclopropyl; and R3 is a radical of formula (IB) wherein Q is hydrogen or an optionally substituted phenyl or monocyclic heterocyclic ring with 5 or 6 ring atoms; Z&It;1> is —S—, —S(O)—, —S(O)2-, —O—, —SO2NH—, —NHSO2-, NHC(═O)NH, —NH(C═S)NH—, Or —N(R4)— wherein R4 is hydrogen, C1-C3 alkyl, cycloalkyl, or benzyl; and Alk&It;1> and Alk&It;2> are, independently, optionally substituted divalent C1-C3 alkylene radicals; and m, n and p are independently 0 or 1.
Public/Granted literature
- US20090247507A1 Enzyme Inhibitors Public/Granted day:2009-10-01
Information query
IPC分类: