Invention Grant
US08088795B2 Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and p53
有权
环烷基胺衍生物作为MDM2和p53相互作用的抑制剂
- Patent Title: Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and p53
- Patent Title (中): 环烷基胺衍生物作为MDM2和p53相互作用的抑制剂
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Application No.: US12293566Application Date: 2007-03-19
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Publication No.: US08088795B2Publication Date: 2012-01-03
- Inventor: Jean Fernand Armand Lacrampe , Christophe Meyer , Bruno Schoentjes , Alain Philippe Poncelet , Camille Georges Wermuth , Bruno Giethlen , Jean-Marie Contreras , Muriel Joubert , Luc Van Hijfte
- Applicant: Jean Fernand Armand Lacrampe , Christophe Meyer , Bruno Schoentjes , Alain Philippe Poncelet , Camille Georges Wermuth , Bruno Giethlen , Jean-Marie Contreras , Muriel Joubert , Luc Van Hijfte
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agent Rajiv S. Shah
- International Application: PCT/EP2007/052582 WO 20070319
- International Announcement: WO2007/107545 WO 20070927
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; A61K31/4439 ; C07D401/14 ; A61P35/00
Abstract:
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1, R2, R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
Public/Granted literature
- US20100168163A1 CYCLIC-ALKYLAMINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 Public/Granted day:2010-07-01
Information query
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