Invention Grant
US08088800B2 4-(5-aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity
有权
4-（5-（氨基甲基） - 吲哚-1-基甲基） - 苯甲酰胺衍生物和作为治疗肥胖症的阿片受体拮抗剂的相关化合物
- Patent Title: 4-(5-aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity
- Patent Title (中): 4-（5-（氨基甲基） - 吲哚-1-基甲基） - 苯甲酰胺衍生物和作为治疗肥胖症的阿片受体拮抗剂的相关化合物
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Application No.: US10598281Application Date: 2005-03-09
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Publication No.: US08088800B2Publication Date: 2012-01-03
- Inventor: Dana Raε Benesh , Maria-Jesus Blanco-Pillado
- Applicant: Dana Raε Benesh , Maria-Jesus Blanco-Pillado
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent John C. Demeter
- International Application: PCT/US2005/007702 WO 20050309
- International Announcement: WO2005/090303 WO 20050929
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/40 ; A01N43/38
Abstract:
The present invention relates to compounds of formulae (I) and (II) useful as opioid receptor antagonists for the treatment of obesity, wherein p is 0, 1, or 2; y is 0, 1, or 2; and z is 0, 1, or 2; X1 is CH2, CH, or N; to form a indolinyl, indolyl, or benzimidazole ring respectively and including applicable double bonds and/or hydrogen atoms; X2 is CH or N; R1 to R7, R3′, p, y, and z are as defined in the claims.
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